Enhancement of speed and efficiency of an Internet based gear design optimisation

An internet-based gear design optimisation program has been developed for geographically dispersed teams to collaborate over the internet. The optimisation program implements genetic algorithm. A novel methodology is presented that improves the speed of execution of the optimisation program by integrating artificial neural networks into the system. The paper also proposes a method that allows an improvement to the performance of the back propagation-learning algorithm. This is done by rescaling the output data patterns to lie slightly below and above the two extreme values of the full range neural activation function. Experimental tests show the reduction of execution time by approximately 50%, as well as an improvement in the training and generalisation errors and the rate of learning of the network

What surface maximizes entanglement entropy?

For a given quantum field theory, provided the area of the entangling surface is fixed, what surface maximizes entanglement entropy? We analyze the answer to this question in four and higher dimensions. Surprisingly, in four dimensions the answer is related to a mathematical problem of finding surfaces which minimize the Willmore (bending) energy and eventually to the Willmore conjecture. We propose a generalization of the Willmore energy in higher dimensions and analyze its minimizers in a general class of topologies $S^m\times S^n$ and make certain observations and conjectures which may have some mathematical significance.Comment: 21 pages, 2 figures; V2: typos fixed, Refs. adde

Multi-user Internet environment for gear design optimization

A Web based multi-user system has been developed to remotely execute a large size software package via the Internet. The software implements genetic algorithm to optimize the design of spur and helical gears. To accomplish this, a combination of HTML, JavaServlets, JavaApplets, JavaScript and HTTP protocol has been employed

Nonlocal mixing of supercurrents in Josephson ballistic point contact

We study coherent current states in the mesoscopic superconducting weak link simultaneously subjected to the order parameter phase difference on the contact and to the tangential to the junction interface superfluid velocity in the banks. The Josephson current-phase relation controlled by the external transport current is obtained. At phase difference close to pi the nonlocal nature of the Josephson phase-dependent current results in the appearance of two vortexlike states in the vicinity of the contact.Comment: 4 pages, 6 figures; to be published in Phys. Rev. B; e-mail: [email protected]

Effect of culture on acceptance of telemedicine in Middle Eastern countries: Case study of Jordan and Syria

© Mary Ann Liebert, INC.We investigated issues that affect the use and adoption of telemedicine in Middle Eastern countries, taking the Hashemite Kingdom of Jordan and the Syrian Arab Republic as case studies. Our study is based on interviews with key stakeholders (including doctors, technicians, engineers, and decision makers) and questionnaires administered to key stakeholders (including patients), ensuring opinion was gained from people from a full range of backgrounds and roles in the healthcare system. We found doctor and patient resistance was a major issue preventing the adoption of telemedicine in both countries, followed by poor infrastructure, lack of funding, and lack of information technology training. Our research identifies that culture is a greater issue than technical matters for the adoption of telemedicine in Middle Eastern countries. Based on our preliminary results we developed a guideline framework for each country that might be applied to telemedicine projects at the pre-implementation phase. The proposed guideline framework was validated through a return visit to the stakeholders and seeking further opinion

Prevalence of exclusive breastfeeding and its determinants in first 6 months of life: A prospective study

Background: Exclusive breastfeeding for first 6 months of life is recommended under Infant and Young Child Feeding practices in India. The objective of present study was to estimate the prevalence of exclusive breastfeeding during first 6 months of life of babies and to identify factors that interfere with the practice in the study area. Methods: A prospective cohort of 462 women who delivered at maternity unit of Government Medical College & Hospital, Rajkot, which is a tertiary care centre for the district, was studied. Data collection was done at hospital as well as during home visits of babies at 1, 3 and 6 months. Factors related to cessation of breastfeeding were analyzed using univariate, bivariate and multivariate analysis. Results: All 462 mothers reported breastfeeding their newborns. Prevalence of exclusive breastfeeding reported at 3 months was 97% which declined to 62% by 6 months of age of infants. Bivariate analysis revealed no significant association between interruption of exclusive breastfeeding before 6 months of age and various demographic, socioeconomic, maternal and infant characteristics. Multivariate analysis by logistic regression demonstrated no association between discontinuation of exclusive breastfeeding and socioeconomic status, maternal education and maternal age, number of antenatal visits, maternal employment and initiation of breastfeeding after delivery. Conclusion: Exclusive breastfeeding prevalence rate found higher than at national level indicating better feeding practices in these part of India. Also, factors classically considered as supportive for breastfeeding had shown no association with breastfeeding pattern in present study

Mesoscopic multiterminal Josephson structures: I. Effects of nonlocal weak coupling

We investigate nonlocal coherent transport in ballistic four-terminal Josephson structures (where bulk superconductors (terminals) are connected through a clean normal layer, e.g., a two-dimensional electron gas). Coherent anisotropic superposition of macroscopic wave functions of the superconductors in the normal region produces phase slip lines (2D analogs to phase slip centres) and time-reversal symmetry breaking 2D vortex states in it, as well as such effects as phase dragging and magnetic flux transfer. The tunneling density of local Andreev states in the normal layer was shown to contain peaks at the positions controlled by the phase differences between the terminals. We have obtained general dependence of these effects on the controlling supercurrent/phase differences between the terminals of the ballistic mesoscopic four-terminal SQUID.Comment: 18 pages, 11 figure

Efficacy and safety of sodium zirconium cyclosilicate in patients with baseline serum potassium level ≥ 5.5 mmol/L: pooled analysis from two phase 3 trials.

BackgroundReliable, timely-onset, oral treatments with an acceptable safety profile for patients with hyperkalemia are needed. We examined the efficacy and safety of sodium zirconium cyclosilicate (SZC; formerly ZS-9) treatment for ≤ 48 h in patients with baseline serum potassium level ≥ 5.5 mmol/L.MethodsData were pooled from two phase 3 studies (ZS-003 and HARMONIZE) among patients receiving SZC 10 g three times daily. Outcomes included mean and absolute change from baseline, median time to potassium level ≤ 5.5 and ≤ 5.0 mmol/L, and proportion achieving potassium level ≤ 5.5 and ≤ 5.0 mmol/L at 4, 24, and 48 h. Outcomes were stratified by baseline potassium. Safety outcomes were evaluated.ResultsAt baseline, 125 of 170 patients (73.5%) had potassium level 5.5-< 6.0, 39 (22.9%) had potassium level 6.0-6.5, and 6 (3.5%) had potassium level > 6.5 mmol/L. Regardless of baseline potassium, mean potassium decreased at 1 h post-initial dose. By 4 and 48 h, 37.5% and 85.0% of patients achieved potassium level ≤ 5.0 mmol/L, respectively. Median (95% confidence interval) times to potassium level ≤ 5.5 and ≤ 5.0 mmol/L were 2.0 (1.1-2.0) and 21.6 (4.1-22.4) h, respectively. Fifteen patients (8.8%) experienced adverse events; none were serious.ConclusionsSZC 10 g three times daily achieved serum potassium reduction and normokalemia, with a favorable safety profile.Trial registrationClinicalTrials.gov identifiers: ZS-003: NCT01737697 and HARMONIZE: NCT02088073